冯赛祥，男，微生物学博士，副教授，硕士生导师。任职于beat365传染病教研室，人兽共患病防控制剂国家地方联合工程实验室。研究兴趣：微生物基因工程，合成生物学。主要从事动物病原菌基因功能研究及基因工程疫苗开发；细菌素生物合成机制及抗菌作用机理等。先后主持国家自然科学基金，国家重点研发计划项目子课题等项目，参与其他国家及省部级课题多项。以第一作者或通讯作者在Journal of Agricultural and Food Chemistry，Applied and Environmental Microbiology，Veterinary Research及Veterinary Microbiology等杂志发表SCI论文22篇，获授权发明专利13件，曾以访问学者身份在美国Virginia Tech及香港科技大学进行访问研究。

2010-09 至 2014-06，华南农业大学，微生物学，博士

2007-09 至 2010-07，华南农业大学，生物化学与分子生物学，硕士

2003-09 至 2007-06，华南农业大学，生物科学，学士

2017-10至今，华南农业大学，beat365，讲师/副教授

2019-12至2020-04，香港科技大学，Department of Chemistry，访问学者

2014-11至2017-07，华南农业大学，beat365，博士后

2013-09至2014-05，Virginia Tech，Virginia-Maryland College of Veterinary Medicine，访问学者

动物病原菌遗传及基因功能研究。

动物病原菌基因工程疫苗开发。

细菌素生物合成机制与应用。

纳米抗体及亚单位疫苗研发。

1.国家重点研发计划，2022YFD1801003，禽重要病毒病新型基因工程亚单位疫苗创制，2022.11-2025.12，子课题主持。

2.国家重点研发计划，2022YFD1800904，新型载体疫苗研发，2022.11-2025.12，子课题主持。

3.国家自然科学基金，31802203，副猪嗜血杆菌磷酸葡萄糖变位酶功能及其与脂寡糖合成关系的研究，2019.01-2021.12，主持。

4.广东省企业科技特派员，GDKTP2021017300，副鸡嗜血杆菌A、B和C型遗传改造及生产工艺优化，2021.11-2023.10，主持。

5.横向课题，家禽新型专用佐剂的研究，2020.07-2021.12，主持。

6.国家自然科学基金，31972762，转录因子BolA调控c-di-GMP通路影响多细胞行为鼠伤寒沙门氏菌耐药性的分子机制研究，2020.01-2023.12，参与。

7.国家重点研发计划，2018YFD0500505，畜禽养殖和屠宰过程中重要人畜共患食源性病原微生物风险评估关键技术和预警模型研究，2018.06-2021.12，参与。

8.广东省应用型科技研发专项，2017B020233003，利用同源重组技术和大规模发酵工艺研制新型动物细菌疫苗及产业化，2017.04至2020.03，参与。

1.Chen, L.; Sun, J.; Hu, J.; Tian, Y.; Du, P.; Guo, Q.; Yang, C.; Zhang, Q.; Feng, S.*; Liao, M. *, Identification and characterization of biosynthetic loci of lipooligosaccharide and capsular polysaccharide in Avibacterium paragallinarum. Vet Microbiol 2024, 299, 110317.

2.Li, Y.; Li, W.; Zhou, D.; Zeng, Z.; Han, Y.; Chen, Q.; Wang, Z.; Wang, G.; Feng, S.*; Cao, W.*, Microcin Y utilizes its stable structure and biological activity to regulate the metabolism of intestinal probiotics and effectively clear gut Salmonella. Int J Biol Macromol 2024, 133290.

3.Shi, K.#; Feng, S.#; Zhao, L.; Chen, J.; Song, W.; Jia, Y.; Qu, X.; Liu, Z.; Jia, W.; Du, S.; Liao, M., N-glycosylation on hemagglutinin head reveals inter-branch antigenic variability of avian influenza virus H5-subtypes. Int J Biol Macromol 2024, 132901.

4.Li, W.; Zeng, Z.; Zhou, D.; Wang, G.; Wang, Z.; Li, Y.; Han, Y.; Qin, M.; Luo, C.; Feng, S.*; Cao, W.*, Effect of oral administration of microcin Y on growth performance, intestinal barrier function and gut microbiota of chicks challenged with Salmonella Pullorum. Vet Res 2024, 55, 66.

5.Zhang, G.#; Feng, S.#; Qin, M.; Sun, J.; Liu, Y.; Luo, C.; Lin, M.; Xu, S.; Liao, M.; Fan, H.; Liang, Z., Influence of PepF peptidase and sporulation on microcin J25 production in Bacillus subtilis. Microbiol Spectr 2024, e0374823.

6.Cao, X.; Huang, X.; Lin, Y.; Sun, J.; Liu, P.; Dong, X.; He, G.; Feng, S.*; Luo, K.*, Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China. Poult Sci 2024, 103, 103751.

7.Huang, X.; Li, W.; Cao, X.; Zhang, Q.; Lin, Y.; Xu, S.; Dong, X.; Liu, P.; Liu, Y.; He, G.; Luo, K.; Feng, S.*, Generation and characterization of a nanobody against the avian influenza virus H7 subtype. Int J Biol Macromol 2024, 267, 131458.

8.Jiang, J.; Zhao, Y.; Chen, A.; Sun, J.; Zhou, M.; Hu, J.; Cao, X.; Dai, N.; Liang, Z.; Feng, S.*, Efficient markerless genetic manipulation of Pasteurella multocida using lacZ and pheSm as selection markers. Appl Environ Microbiol 2024, e0204323.

9.Li, Y.; Li, W.; Zeng, Z.; Han, Y.; Chen, Q.; Dong, X.; Wang, Z.; Feng, S.*; Cao, W.*, Lasso peptide MccY alleviates non-typhoidal salmonellae-induced mouse gut inflammation via regulation of intestinal barrier function and gut microbiota. Microbiol Spectr 2023, 11, e0178423.

10.Guo, L.; Dai, H.; Feng, S.*; Zhao, Y.*, Contribution of GalU to biofilm formation, motility, antibiotic and serum resistance, and pathogenicity of Salmonella Typhimurium. Front Cell Infect Microbiol 2023, 13, 1149541.

11.Zhang, G.; Lin, M.; Qin, M.; Xie, Q.; Liang, M.; Jiang, J.; Dai, H.; Xu, S.; Feng, S.*; Liao, M.*, Establishing Heterologous Production of Microcins J25 and Y in Bacillus subtilis. J Agric Food Chem 2023, 71 (14), 5600-5613.

12.Liu, P.; Dong, X.; Cao, X.; Xie, Q.; Huang, X.; Jiang, J.; Dai, H.; Tang, Z.; Lin, Y.; Feng, S.*; Luo, K.*, Identification of Three Campylobacter Lysins and Enhancement of Their Anti-Escherichia coli Efficacy Using Colicin-Based Translocation and Receptor-Binding Domain Fusion. Microbiol Spectr 2023, 11 (2), e0451522.

13.Han, Y.; Li, Y.; Zeng, Z.; Li, W.; Feng, S.*; Cao, W.*, Resistance Mechanism and Physiological Effects of Microcin Y in Salmonella enterica subsp. enterica Serovar Typhimurium. Microbiol Spectr 2022, e0185922.

14.Li, Y.#; Han, Y.#; Zeng, Z.; Li, W.; Feng, S.*; Cao, W.*, Discovery and Bioactivity of the Novel Lasso Peptide Microcin Y. J Agric Food Chem 2021, 69 (31), 8758-8767.

15.Feng, S.*; Chen, A.; Wang, X.; Pan, Z.; Xu, S.; Yu, H.; Zhang, B.; Liao, M.*, The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis. Vet Res 2020, 51 (1), 97.

16.Zhou, Y.#; Feng, S.#; He, X.; Zhou, Q.; Wang, Y.; Yue, H.; Tang, C.; Zhang, B., Surface-exposed loops L7 and L8 of Haemophilus (Glaesserella) parasuis OmpP2 contribute to the expression of proinflammatory cytokines in porcine alveolar macrophages. Vet Res 2019, 50 (1), 105.

17.Feng, S.; Xu, C.; Yang, K.; Wang, H.; Fan, H.; Liao, M., Either fadD1 or fadD2, Which Encode acyl-CoA Synthetase, Is Essential for the Survival of Haemophilus parasuis SC096. Front Cell Infect Microbiol 2017, 7, 72.

18.Zhou, Q.#; Feng, S.#; Zhang, J.; Jia, A.; Yang, K.; Xing, K.; Liao, M.; Fan, H., Two Glycosyltransferase Genes of Haemophilus parasuis SC096 Implicated in Lipooligosaccharide Biosynthesis, Serum Resistance, Adherence, and Invasion. Front Cell Infect Microbiol 2016, 6, 100.

19.Feng, S. X.; Ma, J. C.; Yang, J.; Hu, Z.; Zhu, L.; Bi, H. K.; Sun, Y. R.; Wang, H. H., Ralstonia solanacearum fatty acid composition is determined by interaction of two 3-ketoacyl-acyl carrier protein reductases encoded on separate replicons. BMC microbiology 2015, 15, 223.

20.Feng, S.; Xu, L.; Xu, C.; Fan, H.; Liao, M.; Ren, T., Role of acrAB in antibiotic resistance of Haemophilus parasuis serovar 4. Vet J 2014, 202 (1), 191-4.

21.Zou, Y.#; Feng, S.#; Xu, C.; Zhang, B.; Zhou, S.; Zhang, L.; He, X.; Li, J.; Yang, Z.; Liao, M., The role of galU and galE of Haemophilus parasuis SC096 in serum resistance and biofilm formation. Vet Microbiol 2013, 162 (1), 278-84.

22.Zhou, S. M.; Xu, C. G.; Zhang, B.; Feng, S. X.; Zhang, L. Y.; Zou, Y.; Liao, M., Natural IgG antibodies in normal rabbit serum are involved in killing of the ompP2 mutant of Haemophilus parasuis SC096 strain via the classical complement pathway. Vet J 2013, 196 (1), 111-3.

23.Zhang, B.; Xu, C.; Zhang, L.; Zhou, S.; Feng, S.; He, Y.; Liao, M., Enhanced adherence to and invasion of PUVEC and PK-15 cells due to the overexpression of RfaD, ThyA and Mip in the Delta ompP2 mutant of Haemophilus parasuis SC096 strain. Vet Microbiol 2013, 162 (2-4), 713-23.

24.Xu, C.; Zhang, L.; Zhang, B.; Feng, S.; Zhou, S.; Li, J.; Zou, Y.; Liao, M., Involvement of lipooligosaccharide heptose residues of Haemophilus parasuis SC096 strain in serum resistance, adhesion and invasion. Vet J 2013, 195 (2), 200-4.

25.Zhang, B.; Xu, C.; Zhou, S.; Feng, S.; Zhang, L.; He, Y.; Liao, M., Comparative proteomic analysis of a Haemophilus parasuis SC096 mutant deficient in the outer membrane protein P5. Microb Pathog 2012, 52 (2), 117-24.

26.Zhang, B.; He, Y.; Xu, C.; Xu, L.; Feng, S.; Liao, M.; Ren, T., Cytolethal distending toxin (CDT) of the Haemophilus parasuis SC096 strain contributes to serum resistance and adherence to and invasion of PK-15 and PUVEC cells. Vet Microbiol 2012, 157 (1-2), 237-42.

27.Zhang, B.#; Feng, S.#; Xu, C.; Zhou, S.; He, Y.; Zhang, L.; Zhang, J.; Guo, L.; Liao, M., Serum resistance in Haemophilus parasuis SC096 strain requires outer membrane protein P2 expression. FEMS Microbiol Lett 2012, 326 (2), 109-15.